Facts About ketamine dose for pain Revealed
Metabolism Ketamine is metabolized via N-dealkylation towards the active metabolite norketamine principally by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation in the cyclohexone ring to type hydroxynorketamine compounds by way of CYP-dependent pathways, which are conjugated with glucuronic aci